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Evidence is increasing that addiction without exception is related to problems with the brain’s reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates “the volume of dopamine released in responding to a stimulus”(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the people who go through it one should err on the side of caution and let the FDA do its job and demand some research be done so the public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on the medications.

Researchers discovered that participants using this drug for a year, dropped a few pounds within four weeks and have kept the extra weight off through the 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which might be made up of many active ingredient, which may make them far better and safer.

Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that by right now there aren’t long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and mustn’t be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must ‘t be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

A pyromaniac, with both psychiatric and medical therapy, can nonetheless be treated. It is best done with behavioral therapy. Psychotherapy treatment alongside behavior modification is easily the most frequently used treatment. Based on the study of Jon Grant, a compounding treatment of drugs and behavioral therapy is discovered to be successful for pyromania. The using serotonin reuptake inhibitors can be beneficial in manipulating the impulsive behavior in the patient as in other impulse control disorder. Also ideal for the patient are medications such as Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), and also other antidepressants.